Comparison between Linked Colour Imaging and White Light Imaging in Predicting Histological Healing of Ulcerative Colitis
Objective The aim of this study is to investigate the predictive value of Linked Colour Imaging(LCI)and White Light Imaging(WLI)in the histological healing of UC mucosa.Methods Colonoscopy was performed on patients with UC in remission,and the colonic mucosa was observed by WLI and LCI,and endoscopic pictures were collected,and the images were classified by Mayo Endoscopic Score(MES)and LCI classification.First,the images collected from LCI were imported into Adobe Photoshop CS4 software,and the redness of the images was digitally analyzed as the LCI index.The correlation between LCI index and LCI grade and histopathological grade was analyzed.Then,the correlation between MES and LCI grades and histopathologic grades of patients was studied.The Spearman correlation coefficient of LCI grade and MES with histopathological grade was calculated.The ability of LCI grading and MES to diagnose histological healing of UC in remission was evaluated by Receiver Operator Characteristic(ROC)Area Under Curve(AUC).Results According to Spearman's correlation analysis,There was a significant correlation between LCI index and LCI grade(r=0.644,P＜0.001).There was a significant correlation between LCI classification and histological healing(r=0.719,P＜0.001),while there was no correlation between MES and histological healing(r=0.125,P＞0.05).The AUC of LCI classification for histological healing was 0.810,and its sensitivity and specificity were70.5％and 81.8％respectively.The AUC of MES for histological healing was 0.647(the sensitivity and specificity were 68.8％and 60.6％,respectively),and the P value between the two was 0.038,and the difference was statistically significant.Conclusion The ability of LCI grade to judge histological healing is higher than that of Mayo endoscopic score.LCI may become a new method for endoscopy,disease evaluation,and histopathology prediction in patients with ulcerative colitis.
Ulcerative ColitisLinked Color ImagingWhite Light ImagingHistological Healing
万方数据
维普
