血清MG53水平与急性心肌梗死患者PCI后发生心肌缺血再灌注损伤的相关性分析
The relationship between serum MG53 post-PCI and myocardial ischemia-reperfusion injury in patients with acute myocardial infarction
姚家芳 1李小旺1
作者信息
- 1. 313000 湖州市第一人民医院心内科
- 折叠
摘要
目的 探讨急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)后血清MG53与心肌缺血再灌注损伤(MIRI)的关系.方法 选择2021年2月至2023年2月湖州市第一人民医院行PCI的AMI患者142例,PCI 1 d后采用酶联免疫吸附法检测血清MG53水平,并检测肌钙蛋白I(cTnI)、D-二聚体(DD)、肌酸激酶同工酶(CK-MB).根据行PCI期间是否发生MIRI将患者分为MIRI组和非MIRI组.比较两组患者PCI后血清MG53水平,绘制ROC曲线,分析血清MG53对AMI患者 PCI后发生MIRI的检测价值.结果 PCI后 61 例出现MIRI,发生率为 42.96%;MIRI组患者血清 MG53 水平为(138.44±45.23)pg/mL,高于非MIRI组的(108.69±25.89)pg/mL,差异有统计学意义(P=0.001).点二列相关性分析显示,血清MG53水平与AMI患者PCI后发生MIRI呈正相关(r=0.386,P＜0.001).ROC曲线显示,血清MG53水平评估AMI患者PCI后发生MIRI的AUC＞0.7,具有一定的检测价值.结论 AMI患者PCI后血清MG53与MIRI之间存在弱相关.
Abstract
Objective To explore the correlation between serum Mitsugumin53(MG53)after percutaneous coronary intervention(PCI)and myocardial ischemia-reperfusion injury(MIRI)in patients with acute myocardial infarction(AMI).Methods A total of 142 AMI patients underwent PCI in the First People's Hospital of Huzhou from February 2021 to February 2023 were enrolled.One day after PCI,serum MG53 was detected using enzyme-linked immunosorbent assay.Meanwhile,cardiac troponin I(cTnI),D-dimer(DD),and creatine kinase isoenzyme(CK-MB)were measured.The patients were divided into MIRI group and non-MIRI group based on whether MIRI occurred during PCI.Serum MG53 were compared between the two groups after PCI.The relation between serum MG53 and MIRI after interventional treatment was analyzed.Results After PCI,61 patients developed MIRI,with an incidence rate of 42.96% .Serum MG53 level in MIRI group(138.44±45.23)pg/mL was significantly higher than that in non-MIRI group(108.69±25.89)pg/mL,P=0.001.Point-Biserial-Correlation analysis showed serum MG53 was positively correlated with the occurrence of MIRI in AMI patients after PCI(r=0.386,P＜0.001).The ROC showed,the AUC of MIRI occurrence after PCI in AMI patients evaluated by serum MG53 level was＞0.7,which had certain value.Conclusion There is a weak correlation between serum MG53 level post-PCI and MIRI in AMI patients.
关键词
急性心肌梗死/经皮冠状动脉介入/心肌缺血再灌注损伤/MG53Key words
Acute myocardial infarction/Percutaneous coronary intervention/Myocardial ischemia reperfusion injury/Mitsugumin53引用本文复制引用
基金项目
湖州市公益性应用研究项目(2023GY23)
出版年
2024
NETL
NSTL
维普
万方数据