Objective To investigate the correlation between atrial natriuretic peptide precursor A(NPPA)gene polymorphism and 5-year all-cause mortality in patients with heart failure with preserved ejection fraction(HFpEF).Methods A total of 233 HFpEF patients admitted to the Ninth People's Hospital of Hangzhou from January 2013 to January 2016 were included.Thirty-one patients died(death group)and 202 patients survived(survival group)during 5-year follow-up.General clinical data and NPPA gene polymorphism were compared between the two groups.Cox regression was used to analyze the factors influencing 5-year all-cause mortality.Serum NT-proBNP was compared between patients with different genotypes.Results The proportion of New York Heart Association(NYHA)class Ⅳ,chronic obstructive pulmonary disease(COPD),atrial fibrillation and chronic renal insufficiency,and serum NT-proBNP were significantly higher in the death group than those in the survival group(both P＜0.05).The results of NPPA gene amplification showed that there were genetic polymorphisms at both rs5063 and rs5065 loci.The proportions of AA genotype and A allele at rs5063 were significantly higher in the death group than those in the survival group(both P＜0.05).NYHA class,COPD,atrial fibrillation,chronic renal insufficiency,NT-proBNP,and AA genotype of rs5063 were the factors influencing 5-year all-cause mortality of patients with HFpEF(all P＜0.05).Serum NT-proBNP was significantly lower in patients with AG and GG genotype of rs5063 and rs5065 than with AA genotype(all P＜0.05).Conclusion NPPA gene polymorphism is one of the factors influencing 5-year all-cause mortality of HFpEF patients.
NETL
NSTL
万方数据
维普
