Objective To compare the value of fractional flow reserve(FFR)and intravascular ultrasound(IVUS)in guiding therapy selection in angina patients with 70% coronary stenosis.Methods Eighty patients with stable angina pectoris who underwent coronary angiography in Xiaoshan District First People's Hospital from December 2019 to April 2022 and showed 70% stenosis were selected.Among them,30 cases each underwent IVUS(IVUS group)and FFR(FFR group)examinations,and 20 cases were only treated conservatively(control group).When the minimum lumen area≤4 mm2 and plaque load≥70% by IVUS,or FFR value≤0.8,percutaneous coronary intervention(PCI)was performed.All patients were given dual antiplatelet therapy,lipid-lowering therapy and β-receptor blocker therapy,and followed up for 9 months.The distribution of coronary lesions,the main adverse cardiovascular events(MACE)such as angina,myocardial infarction,revascularization,and cardiac death were compared between groups.Results The distribution of coronary artery lesions was not significantly different among the three groups(P>0.05).The number of patients underwent PCI was significantly higher in IVUS group than in FFR group(both P<0.05).The incidences of MACE in IVUS group and FFR group were similar,both were significantly lower than that in the control group(P<0.05).Conclusion Both IVUS and FFR can guide the selection of treatment plans for angina patients with 70% coronary artery stenosis.