Objective To construct a model for predicting major adverse cardiovascular event(MACE)in patients with type 2 diabetes mellitus(T2DM)after statin treatment.Methods Three hundred and eighty-seven T2DM patients treated with statins in Lishui Second People's Hospital from January 2018 to December 2021 were included.According to whether MACE occurred during the follow-up period,the patients were divided into MACE group(n=43)and no MACE group(n=344).Clinical data were compared between the two groups of patients.Cox proportional hazards regression model was used to analyze the influencing factors of MACE,and the nomogram of the prediction model was constructed and verified.Results The age,C-reactive protein,total cholesterol,triglycerides,and low density lipoprotein cholesterol(LDL-C)were significantly higher in the MACE group than in the no MACE group(all P＜0.05).C-reactive protein≥2.57 mg/L,total cholesterol≥3.80 mmol/L,triglyceride≥1.10 mmol/L,LDL-C≥1.98 mmol/L were independent risk factors of MACE in T2DM patients after statin treatment(all P＜0.05).The AUCs of the model derived from above four risk factors for prediction of 1-year,3-year,and 5-year MACE were 0.792,0.850 and 0.781,respectively.Hosmer Lemeshow test showed that the discrimination and calibration of the predictive model were relatively good(all P＞0.05).Conclusion The model constructed based on C-reactive protein,total cholesterol,triglyceride and LDL-C has certain predictive power for MACE in T2DM patients after statin treatment.
Type 2 diabetes mellitusStatinsMajor adverse cardiac eventPrediction model
万方数据
维普
