The predictive performance of miR-129-3p and miR-129-5p on the short-term outcome after antiventricular remodeling therapy in acute myocardial infarction patients complicated with heart failure
The predictive performance of miR-129-3p and miR-129-5p on the short-term outcome after antiventricular remodeling therapy in acute myocardial infarction patients complicated with heart failure
Objective To investigate the predictive performance of miR-129-3p and miR-129-5p on the short-term outcome after antiventricular remodeling therapy in acute myocardial infarction(AMI)patients complicated with heart failure(HF).Methods Eighty-seven AMI patients with HF admitted to Jinhua Central Hospital from March 2020 to February 2021 were included.The expression of miR-129-3p and miR-129-5p were compared between improved and unimproved patients before and after 1 and 2 months of antiventricular remodeling therapy.ROC curve analysis was used to evaluate the predictive efficacy of miR-129-3p and miR-129-5p expression on short-term outcome after antiventricular remodeling therapy.Results After antiventricular remodeling therapy,62 cases showed improvement(improved group),while 25 cases showed no improvement(umimproved group).After 2 months of treatment,the effective rate was 71.3%.There was no significant difference in the expression levels of miR-129-3p and miR-129-5p between the two groups before treatment(all P＞0.05).The expression of miR-129-3p and miR-129-5p increased significantly after 1 and 2 months of treatment in both groups,which were significantly higher in the improved group than in the umimproved group(all P＜0.05).The AUCs of miR-129-3p,miR-129-5p alone and in combination for predicting heart function improvement were 0.816,0.817,and 0.934,respectively.Conclusion The detection of miR-129-3p and miR-129-5p can predict the short-term efficacy of antiventricular remodeling therapy in AMI patients with HF,and the combined detection efficiency is better.
维普
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