Objective To explore the changes of serum procalcitonin(PCT),interleukin-6(IL-6),serum amyloid-A(SAA),N-terminal pro-brain natriuretic peptide(NT-proBNP)and their relationship with prognosis of patients with chronic heart failure(CHF)and pulmonary infection.Methods Forty-nine CHF patients with pulmonary infection(observation group)and 49 CHF patients(control group)admitted to Hangzhou Xixi Hospital Affiliated to Zhejiang University School of Medicine from January 2019 to January 2023 were enrolled.The serological indexes(PCT,IL-6,SAA,NT-proBNP),cardiac function indexes[left ventricular fractional shortening(LVFS),left ventricular ejection fraction(LVEF)]and the incidence of major adverse cardiovascular event(MACE)at admission were compared between the two groups.The serum measurements at admission and on the 3 d and 7 d after treatment were compared between the patients with and without MACE in the observation group.Results At admission,serum PCT,IL-6,SAA and NT-proBNP,and the incidence of MACE in the observation group were significantly higher than those in the control group(all P＜0.05),while LVFS and LVEF were significantly lower than those in the control group(all P＜0.05).In the observation group,PCT,IL-6,SAA and NT-proBNP were negatively correlated with LVEF(r=-0.645,-0.474,-0.390,-0.615,all P＜0.05).PCT,IL-6,SAA and NT-proBNP at admission and on the 3 d and 7 d after treatment were significantly higher in patients with than without MACE in the observation group(all P＜0.05).Conclusion Serum PCT,IL-6,SAA and NT-proBNP increase in CHF patients with pulmonary infection and are related to poor outcome.
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