摘要
目的 探讨慢性心力衰竭(CHF)伴肺部感染患者血清降钙素原(PCT)、白细胞介素 6(IL-6)、血清淀粉样蛋白A(SAA)、氨基末端脑钠肽前体(NT-proBNP)变化及其与预后的关系.方法 选取2019年 1月至2023年 1月浙江大学医学院附属杭州市西溪医院收治的49例CHF伴肺部感染患者为观察组,另选取同期本院收治的49例单纯CHF患者为对照组.比较两组患者入院时血清学指标(包括PCT、IL-6、SAA、NT-proBNP)、心功能指标[包括左心室短轴缩短率(LVFS)、左心室射血分数(LVEF)]以及主要不良心血管事件(MACE)发生率,以及观察组有无MACE患者入院时及治疗 3、7d后血清学指标差异.结果 观察组患者入院时PCT、IL-6、SAA、NT-proBNP水平以及MACE发生率均明显高于对照组,LVFS、LVEF均明显低于对照组,差异均有统计学意义(均P＜0.05).观察组患者PCT、IL-6、SAA、NT-proBNP与LVEF均呈负相关(r=-0.645、-0.474、-0.390、-0.615,均P＜0.05).观察组MACE患者入院时以及治疗3、7d后PCT、IL-6、SAA、NT-proBNP水平均明显高于无MACE患者,差异均有统计学意义(均P＜0.05).结论 CHF伴肺部感染患者血清 PCT、IL-6、SAA、NT-proBNP水平均明显升高,且与不良预后有关.
Abstract
Objective To explore the changes of serum procalcitonin(PCT),interleukin-6(IL-6),serum amyloid-A(SAA),N-terminal pro-brain natriuretic peptide(NT-proBNP)and their relationship with prognosis of patients with chronic heart failure(CHF)and pulmonary infection.Methods Forty-nine CHF patients with pulmonary infection(observation group)and 49 CHF patients(control group)admitted to Hangzhou Xixi Hospital Affiliated to Zhejiang University School of Medicine from January 2019 to January 2023 were enrolled.The serological indexes(PCT,IL-6,SAA,NT-proBNP),cardiac function indexes[left ventricular fractional shortening(LVFS),left ventricular ejection fraction(LVEF)]and the incidence of major adverse cardiovascular event(MACE)at admission were compared between the two groups.The serum measurements at admission and on the 3 d and 7 d after treatment were compared between the patients with and without MACE in the observation group.Results At admission,serum PCT,IL-6,SAA and NT-proBNP,and the incidence of MACE in the observation group were significantly higher than those in the control group(all P＜0.05),while LVFS and LVEF were significantly lower than those in the control group(all P＜0.05).In the observation group,PCT,IL-6,SAA and NT-proBNP were negatively correlated with LVEF(r=-0.645,-0.474,-0.390,-0.615,all P＜0.05).PCT,IL-6,SAA and NT-proBNP at admission and on the 3 d and 7 d after treatment were significantly higher in patients with than without MACE in the observation group(all P＜0.05).Conclusion Serum PCT,IL-6,SAA and NT-proBNP increase in CHF patients with pulmonary infection and are related to poor outcome.
维普
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