Objective To investigate the effects of rapamycin eluting stents on vascular endothelial function and inflammatory cytokines in patients with coronary heart disease(CHD).Methods Two hundred CHD patients underwent percutaneous coronary intervention(PCI)in Linhai Second People's Hospital from May 2019 to March 2023 were included.Among them,100 cases were implanted with rapamycin eluting stents(observation group)and 100 cases were implanted with cobalt-based stents(control group).The hemodynamic parameters(including mean arterial pressure and heart rate),plasma endothelin-1 and serum inflammatory factors(including C-reactive protein and interleukin-6)were measured before stent implantation(T1),at 30 min after stent implantation(T2),immediately after stent implantation(T3),in 3 months after stent implantation(T4),and 6 months after stent implantation(T5)were observed and compared between the two groups.Results The success rate of PCI was significantly higher in the observation group than in the control group(97.0%vs.89.0%,P=0.027).There were significant differences in hemodynamic parameters,plasma endothelin-1 levels and serum inflammatory factors at different time points before and after stent implantation between the two groups(all P＜0.01).The levels of endothelin 1,C-reactive protein and interleukin 6 at T2,T3,T4 and T5 in observation group were significantly lower than those in control group(all P＜0.01).The total incidence of postoperative complications in the observation group was significantly lower than that in the control group(7.0%vs.18.0%,P=0.019).Conclusion Rapamycin eluting stent has certain effects on vascular endothelial function and inflammatory cytokines in CHD patients,but less effective and higher safety than that of cobalt-based stents.
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