Objective To investigate the changes in serum stromal cell-derived factor-1α(SDF-1α)in patients with ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI)and limb remote ischemic conditioning(RIC)and its association with ventricular remodeling.Methods A retrospective study was conducted on 70 patients with STEMI who underwent emergency PCI in Nanjing Gaochun People's Hospital from January 2020 to July 2022.Among them,37 patients received PCI+RIC(RIC group)and 33 patients only recived PCI(control group).Serum SDF-1α concentration before and after PCI,cardiac function[Including left ventricular ejection fraction(LVEF),left ventricular end-diastolic dimension(LVEDd),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV)]at 3 days and 1 year after PCI and corrected thrombolysis in myocardial infarction frame count(CTFC)between the two groups were compared.Pearson correlation was used to analyze the correlation between serum SDF-1α concentration immediately after PCI and cardiac function index 1 year after PCI.Results The serum SDF-1α concentration in both groups was significantly increased after PCI,and RIC group was higher than control group,the differences were statistically significant(all P＜0.05).RIC group CTFC was lower than the control(P=0.005).The LVEF of RIC group at 3 days after PCI was higher than that of control group(P=0.038).There were no significant differences in LVEDd,LVEDV,LVESV 3 days after surgery and LVEF,LVEDd,LVEDV,LVESV 1 year after PCI(all P＞0.05).The serum SDF-1α concentration immediately after PCI was negatively correlated with LVEDd,LVEDV and LVESV 1 year after PCI(r=-0.338,-0.296,-0.314,all P＜0.05).Conclusion Serum SDF-1α level significantly elevated in STEMI patients after PCI and RIC,and this increase is associated with improved ventricular remodeling.
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