Objective To investigate the changes of serum carcinoembryonic antigen(CEA)and pericardial effusion in patients with hypothyroidism.Methods A total of 327 patients with chest tightness and/or palpitations who were admitted to Affiliated Jinhua Hospital,Zhejiang University School of Medicine from January 2021 to December 2022 were retrospectively enrolled.Among them,patients with hypothyroidism(hypothyroid group),hyperthyroidism(hyperthyroid group)and normal thyroid function(control group)each account 109.Tumor markers,biochemical indicators and incidence of pericardial effusion were compared among the three groups.Patients with elevated CEA in the hypothyroid group were treated with levothyroxine tablet.Thyroid stimulating hormone(TSH),CEA level and pericardial effusion volume were compared before and after treatment.Logistic regression model was used to analyze the factors associated with elevated CEA.Pearson correlation analysis was used to analyze the association of CEA with TSH,tetraiodothyronine(TT4)and free thyroxine(FT4).Results The level of CEA and the incidence of pericardial effusion were significantly higher in the hypothyroid group than in the hyperthyroid group and the control group(all P＜0.05).There were 42 patients with elevated CEA in the hypothyroid group.CEA level and pericardial effusion volume were significantly lower after treatment than before treatment(all P＜0.01).Logistic regression model showed that TSH was an independent factor related to CEA increasing(OR=1.019,P＜0.01).Pearson correlation analysis showed that CEA was positively correlated with TSH(r=0.339,P＜0.01)and negatively correlated with TT4 and FT4(r=-0.424,-0.335,both P＜0.01).Conclusion Patients with hypothyroidism have elevated serum CEA level and an increased incidence of pericardial effusion.Levothyroxine replacement therapy can reduce CEA level and pericardial effusion volume.
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