Ischemic stroke is a disease with high mortality and morbidity rates,and large-core cerebral infarction represents a particularly severe form of the disease.Currently,early endovascular treatment is one of the main treatment modalities.Recent clinical studies on endovascular therapy for large-core cerebral infarction,including RESCUE-Japan LIMIT,ANGEL-ASPECT,SELECT 2,TENSION,and LASTE,have been published,but some details still remain uncertainly.This paper will provide some narrations and comments by reviewing the research status and the characters of these five trials about large-core cerebral infarction.