摘要
目的 探讨高血压合并广泛性焦虑障碍(GAD)患者脑电超慢波信息(EFG)变化.方法 回顾性选取2022年1月至2023年12月浙江中医药大学附属第二医院收治的40例高血压合并GAD患者为研究组,40例高血压(不伴GAD)患者为高血压组,40名体检的健康志愿者为对照组,比较3组对象症状自评量表(SCL-90)评分、EFG检测结果[包括脑电超慢波绝对功率、脑电超慢波相对功率、全脑总功率及脑功能指数],采用Pearson相关分析SCL-90总分与EFG检测结果的相关性.结果 与对照组比较,研究组SCL-90总分及各因子评分均较高(均P＜0.05),高血压组SCL-90总分及躯体化、强迫、抑郁、焦虑、恐怖评分均较高(均P＜0.05);与高血压组比较,研究组总分及躯体化、强迫、人际敏感、抑郁、焦虑和偏执6个因子评分均较高(均P＜0.05).与对照组比较,研究组γ-氨基丁酸(GABA)绝对功率和谷氨酸(Glu)、GABA相对功率、血管舒缩指数均较低(均P＜0.05),去甲肾上腺素(NE)、5-羟色胺(5-HT)绝对功率和5-HT、NE、多巴胺(DA)相对功率均较高(均P＜0.05);高血压组Glu相对功率、血管舒缩指数均较低(均P＜0.05),5-HT绝对功率、5-HT相对功率均较高(均P＜0.05).与高血压组比较,研究组NE绝对功率、5-HT绝对功率和5-HT相对功率均较高(均P＜0.05),GABA绝对功率、GABA相对功率均较低(均P＜0.05).研究组5-HT相对功率与SCL-90总分呈正相关(P=0.048).结论 高血压合并GAD患者存在明显的脑内神经递质失调,且5-HT相对功率与临床表现有关.
Abstract
Objective To explore the changes in electroencephalographic ultra-slow wave information(EFG)in patients with hypertension combined with generalized anxiety disorder(GAD).Methods The study retrospectively selected 40 hypertensive patients combined with GAD treated at the Second Affiliated Hospital of Zhejiang Chinese Medical University from January 2022 to December 2023 as the study group.Another 40 hypertensive patients without GAD were included as the hypertension group,and 40 healthy volunteers undergoing physical examinations served as the control group.The three groups were compared in symptom checklist-90(SCL-90)scores and EFG results(including absolute power of ultra-slow waves,relative power of ultra-slow waves,total brain power,and brain function index).Pearson correlation analysis was used to assess the correlation between the total SCL-90 score and EFG results.Results Compared with the control group,the total SCL-90 score and scores of each factor in the study group were significantly higher(all P＜0.05).The total SCL-90 score and scores for somatization,obsession,depression,anxiety and phobia in the hypertension group were also higher than those of the control group(all P＜0.05).Compared to the hypertension group,the study group had higher scores for total scale,somatization,obsession,interpersonal sensitivity,depression,anxiety and paranoia(all P＜0.05).Compared with the control group,the study group showed lower absolute power of gamma-aminobutyric acid(GABA),relative power of glutamate(Glu)and GABA,and lower vasomotor index(P＜0.05),while its absolute power of norepinephrine(NE)and 5-hydroxytryptamine(5-HT),and the relative power of 5-HT,NE and dopamine(DA)were higher(all P＜0.05).In the hypertension group,the relative power of Glu and the vasomotor index were lower than the control group(both P＜0.05),while the absolute power and relative power of 5-HT were higher(both P＜0.05).Compared with the hypertension group,the study group had higher absolute power of NE and 5-HT,and relative power of 5-HT(P＜0.05),while the absolute power and relative power of GABA were lower(P＜0.05).The relative power of 5-HT in the study group was positively correlated with the total SCL-90 score(P=0.048).Conclusion Patients with hypertension combined with GAD exhibit significant neurotransmitter dysregulation in the brain,and the relative power of 5-HT is associated with clinical manifestations.
维普
万方数据