Objective To analyze the efficacy and safety of radiofrequency catheter ablation(RFCA)for atrial fibrillation(AF)in patients with rheumatic heart disease(RHD).Methods The data of 47 patients with RHD and AF who underwent RFCA in the First Affiliated Hospital of Ningbo University from January 2016 to November 2022 were analyzed retrospectively.The patients were divided into relapse group and non-relapse group based on whether AF reoccurred during 3-months follow up.The clinical features of patients and catheter ablation procedure time were compared between the two groups.Results The procedure time and X-ray exposure time of initial ablation was(128.6±31.4)mins and 7.2(4.1,12.0)mins,respectively.There were 1 case of moderate to large pericardial effusion and 1 case of pseudo-aneurysm after the procedure.There was no AF relapsed in 55.6%patients after initial ablation and in 62.2%patients after repeat ablation during 29(6,48)months follow up.The course of the disease and the procedure time were 54 months and(139.4±23.2)min in relapse group,respectively,significantly higher than 24 months and(120.3±35.0)min in non-relapse group(all P<0.05).The proportions of persistent AF(85.0%vs.48.0%)and valve replacement(35.0%vs.8.0%)were significantly higher in relapse group than in non-relapse group(all P<0.05).Kaplan-Meier curve analysis showed that the cumulative time without AF after initial ablation was significantly higher in patients with paroxysmal AF than in patients with persistent AF(P<0.05).Conclusion The total efficacy after repeat ablation is over 60%for AF patients with RHD.The procedure risk is lower.