Objective To investigate the association of serum creatinine(Scr)and cardiac troponin Ⅰ(cTnⅠ)with echocardiographic parameters and prognosis of patients with sepsis-induced cardiac dysfunction.Methods A total of 164 patients with sepsis treated in Shaoxing Second Hospital from August 2019 to January 2022 were enrolled.Scr and cTnⅠ were measured and echocardiography was performed within 24 h after admission.Echocardiographic para-meters included left ventricular end diastolic diameter(LVEDd),left ventricular end systolic diameter(LVESd),left atrial diameter(LAD),left ventricular ejection fraction(LVEF),stroke volume(SV),ratio of peak E velocity of early diastolic filling peak to peak A velocity of late diastolic filling peak(E/A)and ratio of peak velocity of mitral valve in early diastole to motion velocity of mitral annulus in early diastole(E/e').Pearson correlation analysis was used to analyze the correlation between Scr and cTnⅠ and echocardiographic indexes.Multivariate logistic regression analysis was used to determine the risk factors for 28-day mortality of patients with sepsis-induced cardiac dysfunction.The value of single and combination of Scr and cTnⅠ for predicting outcomes was analyzed using receiver operating characteristic(ROC)curve.Results There were 46 cases with cardiac systolic dysfunction,38 cases with cardiac diastolic dysfunction and 80 cases with normal cardiac function.Pearson correlation analysis showed that Scr and cTnⅠ were positively correlated with LVEDd,LVESd,LAD and E/e'in patients with sepsis-induced cardiac dysfunction(all P＜0.05),but negatively correlated with LVEF,SV and E/A(all P＜0.05).During 28-day of follow-up,49 patients died(58.33％)among 84 patients with cardiac dysfunction.Scr,cTnⅠ,LVEDd,LVESd,LAD and E/e1 in the death group were significantly higher than those in the survival group,while LVEF,SV and E/A were significantly lower than those in the survival group(all P＜0.05).Multivariate logistic regression analysis showed that age,LVEDd,LVESd,LAD,LVEF,SV,E/A,E/e',Scr and cTnⅠwere the risk factors for 28-day mortality in patients with cardiac dysfunction(all P＜0.05).ROC curve showed that the area under the curve of combined Scr and cTnⅠ was significantly higher than that of single for predicting 28-day mortality in patients with cardiac dysfunction(both P＜0.05).Conclusion Scr and cTnⅠ are correlated to echocardio-graphic parameters and short-term outcome of patients with sepsis-induced cardiac dysfunction.
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