油性、非油性鱼类摄入与前列腺癌的因果关联:两样本孟德尔随机化研究
Causal association of oiled and non-oiled fish intake with prostate cancer:a two-sample Mendelian randomization study
陈康 1张家毅 1高伟兴1
作者信息
- 1. 063000 河北省唐山市,华北理工大学附属医院
- 折叠
摘要
目的 采用两样本孟德尔随机化(mendelian randomization,MR)分析方法,探讨油性、非油性鱼类摄入与前列腺癌之间的因果关联.方法 英国生物银行提供了油性和非油性鱼摄入量的全基因组关联研究(GWAS)数据.芬兰数据库提供了前列腺癌GWAS数据.采用了反方差加权(IVW)作为两样本孟德尔随机化分析的主要方法.同时进行异质性和水平多效性检验以确保结果的稳健性.结果 当油性鱼类摄入作为暴露时,IVW分析显示存在显著的相关性(P=0.004,B=0.72),且IVW的方向性和其余三个分析相一致.当非油性鱼类摄入为暴露时,IVW未发现与前列腺癌具有相关性(P=0.09,B=1.29),且使用MR Egger、Weighted Median和Weighted mode方法进行了进一步的分析,仍未发现明显相关性.结论 研究结果表明,摄入油性鱼类可能增加患前列腺癌的风险,非油性鱼类摄入与前列腺癌无相关性.
Abstract
Objective To investigate the causal association between oiled and non-oiled fish intake and prostate cancer using two-sample mendelian randomization(MR)analysis.Methods Genome-wide association study(GWAS)data on the intake of oily and non-oily fish were obtained from the UK Biobank.Prostate cancer GWAS data for this study were provided by the Finnish database.Inverse variance weighting(IVW)was employed as the primary method for the two-sample Mendelian randomization analysis.Concurrent heterogeneity and horizontal pleiotropy analyses were conducted to ensure the robustness of the results.Results When oily fish intake was used as exposure,the IVW analysis showed a significant correlation(P=0.004,B=0.72),and the directionality of the IVW was consistent with the remaining three analyses.When non-oily fish intake was exposure,IVW showed no association with prostate cancer(P=0.09,B=1.29),and further analysis using MR Egger,Weighted Median,and Weighted mode methods still revealed no significant association.Conclusion The study findings suggest that consuming oily fish may increase the risk of prostate cancer,whereas the intake of non-oily fish is not correlated with prostate cancer.
关键词
油性鱼类/前列腺癌/全基因组关联研究/因果推断/孟德尔随机化Key words
Oily fish/Prostate cancer/Genome-wide association study/Causal inference/Two-sample mendelian randomization analysis引用本文复制引用
出版年
2024
NETL
NSTL
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