摘要
目的 探讨六君子汤加味结合针刺治疗慢性阻塞性肺疾病(简称慢阻肺)的临床效果.方法 将2021年3月-2023 年 6 月医院收治的 82 例慢阻肺患者,按照组间基线资料均衡可比原则分为对照组及观察组,各 41 例.对照组患者给予慢阻肺疾病常规临床治疗,观察组在对照组基础上结合六君子汤加味及针刺治疗.对比两组患者的临床疗效,中医症候(胸闷、气促、咳嗽、咯痰)积分,C-反应蛋白(CRP)、降钙素原(PCT)、白细胞计数(WBC)等炎症因子指标,1s用力呼气容积(FEV1)与1s用力呼气容积占用力肺活量比值(FEV1%)等肺功能指标变化,以及不良反应发生情况.结果 治疗后,观察组患者治疗总有效率为 95.12%,高于对照组 80.49%,差异有统计学意义(P<0.05).治疗前,两组患者的中医症候(胸闷、气促、咳嗽、咯痰)积分、CRP及PCT、WBC、FEV1 以及FEV1%等指标比较,差异无统计学意义(P>0.05);治疗后,两组患者的中医症候积分(胸闷、气促、咳嗽、咯痰),CRP、PCT、WBC,FEV1 以及FEV1%等指标均改善,但观察组患者指标改善程度均优于对照组,差异有统计学意义(P<0.05).观察组与对照组患者治疗期间不良反应率均较低,组间差异无统计学意义(P>0.05).结论 六君子汤加味结合针刺治疗慢阻肺可提高临床治疗效果,改善患者症状及肺功能,降低机体炎性反应,且不良反应较少.
Abstract
Objective To explore the clinical effect of Liujunzi decoction combined with acupuncture in treating chronic obstructive pulmonary disease(COPD).Methods A total of 82 COPD patients admitted to the hospital from March 2021 to June 2023 were divided into control group and observation group according to the principle of balanced and comparable baseline data,with 41 cases in each group.The control group was given conventional clinical treatment of COPD disease.The observation group was combined with the treatment of Lijunzi decoction and acupuncture on the basis of the control group.The clinical efficacy,scores of TCM symptoms(chest tightness,shortness of breath,cough,phlegm),C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC)and other inflammatory factors of the two groups were compared.Changes of lung function indexes such as 1s forced expiratory volume(FEV1)and 1s forced expiratory volume ratio to forced vital capacity(FEV1%),and the occurrence of adverse reactions.Results After treatment,the total effective rate of observation group was 95.12%,higher than that of control group 80.49%,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the scores of TCM symptoms(chest tightness,shortness of breath,cough,phlegm),CRP,PCT,WBC,FEV1 and FEV1%between the two groups(P>0.05).After treatment,TCM syndrome scores(chest tightness,shortness of breath,cough,phlegm),CRP,PCT,WBC,FEV1 and FEV1%of patients in both groups were improved,but the improvement degree of patients in observation group was better than that in control group,the difference was statistically significant(P<0.05).The adverse reaction rate of observation group and control group was lower,but there was no statistical significance(P>0.05).Conclusion Liujunzi Decoction combined with acupuncture in the treatment of COPD can improve the clinical therapeutic effect,improve the symptoms and lung function of patients,reduce the inflammatory reaction of the body,and the adverse reaction is less.
NETL
NSTL
万方数据