运动与心肌保护
Exercise and cardioprotection
胡友成 1郑桓 1马虎 2习瑾昆1
作者信息
- 1. 063210 河北省唐山市,华北理工大学基础医学院
- 2. 063210 河北省唐山市,华北理工大学体育部
- 折叠
摘要
运动是预防和减轻心脏疾病经济而有效的非药物干预手段.线粒体相关内质网膜(mitochondria-associated endoplasmic reticulum membranes,MAMs)是心脏相关疾病的重要治疗靶点,MAMs 通过改变其调节蛋白和功能导致内质网应激(endoplasmic reticulum stress,ERS)及线粒体功能障碍,并通过自噬、氧化损伤、凋亡等途径参与心肌保护.运动通过MAMs介导线粒体和内质网之间相互作用,共同介导疾病的发生、发展与转归.通过对运动与心肌保护的作用及机制进行综述,为临床研究提供新策略.
Abstract
Exercise is an economical and effective non-pharmacological intervention to prevent and reduce heart disease.Mitochondria-associated endoplasmic reticulum membranes(MAMs)are important therapeutic targets for cardiac-related diseases.MAMs cause endoplasmic reticulum stress(ERS)and mitochondrial dysfunction by changing their regulatory proteins and functions,and participate in myocardial protection through autophagy,oxidative damage,apoptosis and other pathways.Exercise mediates the interaction between mitochondria and endoplasmic reticulum through MAMs,which jointly mediates the occurrence,development and outcome of diseases.This article reviews the myocardial protection effect of exercise regulation of MAMs,and provides a new strategy for clinical research.
关键词
运动/心肌保护/线粒体相关内质网膜/内质网应激Key words
Exercise/Cardioprotection/MAMs/ERS引用本文复制引用
基金项目
国家自然科学基金(82270303)
河北省社会科学基金(HB20TY012)
出版年
2024
NETL
NSTL
万方数据