Wnt/β-catenin信号通路在急性肺损伤/急性呼吸窘迫综合征中的研究进展
Research progress of Wnt/β-catenin signaling pathway in acute lung injury/acute respiratory distress syndrome
闫凡 1柯雨仙 1姜轶1
作者信息
- 1. 610000 四川省成都市,成都医学院;成都医学院第一附属医院呼吸危重症医学科;老年呼吸病四川省高等学校重点实验室
- 折叠
摘要
急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)发病病因和机制复杂,病死率高居不下,目前尚无特效的治疗药物.最近研究发现,Wnt/β-catenin信号通路在ALI/ARDS中具有重要作用,如可减轻炎症反应及氧化应激、调节凝血和纤溶系统、调控细胞凋亡及铁死亡,从而达到减轻肺损伤的目的.深入研究Wnt/β-catenin信号通路在ALI/ARDS发病机制中的作用,可为ALI/ARDS的临床治疗提供新方向和策略.
Abstract
Acute lung injury/acute respiratory distress syndrome(ALI/ARDS)has complicated etiology and mechanism,and the mortality rate remains high.At present,there is no specific therapeutic drug.It has been found that Wnt/β-catenin signaling pathway can alleviate inflammatory reaction and oxidative stress,regulate coagulation and fibrinolysis system,regulate cell apoptosis and iron death in ALI/ARDS,so as to alleviate lung injury.This article reviews the role of Wnt/β-catenin signaling pathway in the pathogenesis of ALI/ARDS and drug treatment,so as to provide new directions and strategies for clinical treatment of ALI/ARDS.
关键词
Wnt/β-catenin信号通路/急性肺损伤/急性呼吸窘迫综合征Key words
Wnt/β-catenin signaling pathway/Acute lung injury/Acute respiratory distress syndrome引用本文复制引用
基金项目
成都医学院第一附属医院专项科研项目(2019)(CYFY2019GLPHX03)
出版年
2024
NETL
NSTL
万方数据