维生素C在分化型甲状腺癌术后131I治疗中的应用效果
Efficacy of vitamin C in 131I treatment after surgery for differentiated thyroid cancer
曾令鹏 1张庆 1张青1
作者信息
- 1. 330006 江西省南昌市,南昌大学第一附属医院
- 折叠
摘要
目的 探讨维生素C对术后首次行 131I治疗的分化型甲状腺癌(DTC)患者唾液腺功能的影响,并探讨给予维生素C的最佳时间.方法 选取2021年1月-2023年6月在院行 131I治疗的患者为研究对象,将 131I治疗后给予维生素含服的患者作为观察组,不给予维生素含服的患者为对照组.观察组患者根据给予维生素C的时间,分为 2h组和24h组.治疗1周内观察急性唾液腺损伤发生情况;三组患者分别于 131I前及131I后6个月行唾液腺动态显像,计算第15min摄取指数(UI)、排泌分数(SR)参数,以评估唾液腺功能变化.结果 三组患者 131I治疗后急性唾液腺损伤发生率差异无统计学意义(P>0.05).131I治疗后患者双侧腮腺 15min UI较治疗前均出现了明显降低,但组间差异无统计学意义(P>0.05).治疗前后双侧腮腺SR、双侧颌下腺的 15min UI及SR均无明显变化,治疗后的组间差异均无统计学意义(P>0.05).结论 DTC 患者术后首次 131I治疗后唾液腺排泌功能可能受损,不同时间点给予维生素C含服对唾液腺没有明显保护作.
Abstract
Objective To investigate the effect of vitamin C on salivary gland function in patients with differentiated thyroid cancer(DTC)who underwent 131I treatment for the first time after surgery,and to explore the optimal time for vitamin C administration.Method Patients who received 131I treatment at our department from January 2021 to June 2023 were selected as the research subjects.Patients who received vitamin containing treatment after 131I treatment were selected as the observation group,while patients who did not receive vitamin containing treatment were selected as the control group.The observation group patients were divided into a 2-hour group and a 24-hour group based on the duration of vitamin C administration.Observe the occurrence of acute salivary gland inflammation within one week of treatment;Three groups of patients underwent salivary gland dynamic imaging before and 6 months after 131I,and the 15th minute uptake index(UI)and excretion score(SR)parameters were calculated to evaluate changes in salivary gland function.Result There was no statistically significant difference in the incidence of acute salivary gland inflammation among the three groups of patients after 131I treatment(P>0.05).After 131I treatment,the UI of bilateral parotid glands in patients significantly decreased after 15 minutes,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the 15 minute UI and SR of bilateral parotid gland and bilateral submandibular gland before and after treatment(P>0.05).By comparing the data of three groups after treatment,the results showed that there was no statistically significant difference(P>0.05)in the UI and SR of bilateral parotid glands and bilateral submandibular glands at different starting times when vitamin C was taken.Conclusion After the first 131I treatment for DTC patients after surgery,the salivary gland secretion function may be impaired.Taking vitamin C does not have a significant protective effect on the salivary glands.Administration of vitamin C at different time points has little effect on the uptake and excretion function of the salivary glands.
关键词
甲状腺肿瘤/唾液腺/131I/维生素CKey words
Thyroid tumor/Salivary glands/131I/Vitamin C引用本文复制引用
基金项目
江西省卫生健康委科技项目(202130260)
出版年
2024
NETL
NSTL
万方数据