Effect of telmisartan combined with sorbitan nitrate tablets on left ventricular ejection fraction(LVEF)and serum inflammatory factor levels in patients with coronary artery disease combined with hypertension
Objective To observe and analyze the effects of telmisartan combined with isosorbide dinitrate tablets on left ventricular ejection fraction(LVEF)and serum inflammatory factor levels in patients with coronary heart disease and hypertension.Method From January 2023 to February 2024,patients with coronary heart disease and hypertension admitted to the hospital were selected as the research subjects.Among them,44 patients who received telmisartan+conventional coronary heart disease treatment were selected as the control group,and 56 patients who received telmisartan combined with isosorbide dinitrate tablets+conventional coronary heart disease treatment were selected as the observation group.Observe the LVEF levels,serum inflammatory factor levels,and incidence of adverse reactions in two groups of patients.Results There was no statistically significant difference in LVEF levels and levels of inflammatory factors such as IL-6,hs-CRP between the two groups of patients before treatment(P＞0.05).After 15 and 30 days of treatment,the LVEF levels of both groups of patients gradually increased,but the LVEF levels of the observation group were higher than those of the control group at all time points,and the differences between the groups were statistically significant(P＜0.05);After 30 days of treatment,the levels of IL-6 and hs-CRP in both groups of patients decreased,but the levels of various serum inflammatory factors in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the incidence of adverse reactions in the two groups of patients was similar,and the difference was not statistically significant(P＞0.05).Conclusion For patients with coronary heart disease and hypertension,the combination of telmisartan and isosorbide dinitrate tablets can significantly improve LVEF levels and inhibit the action of inflammatory factors,with good safety.
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