碳酸氢钠肝动脉灌注联合肝动脉化疗栓塞术治疗中晚期原发性肝癌的临床效果
Clinical efficacy of sodium bicarbonate hepatic artery infusion combined with hepatic artery chemotherapy embolization in the treatment of advanced primary liver cancer
李晋1
作者信息
- 1. 450052 河南省郑州市,郑州大学第五附属医院介入科
- 折叠
摘要
目的 探讨中晚期原发性肝癌(HCC)患者采用碳酸氢钠肝动脉灌注联合肝动脉化疗栓塞术(TACE)治疗的临床效果.方法 选取2020年12月-2023年1月郑州大学第五附属医院收治的70例中晚期HCC患者,根据组间基线资料均衡可比的原则,以随机数字表法分成观察组(n=35)与对照组(n=35),对照组给予TACE治疗,观察组给予碳酸氢钠肝动脉灌注联合TACE治疗,对比分析两组患者近期疗效、肿瘤标志物及肝功能指标.结果 观察组患者的客观有效率(ORR)为74.29％(26/35),较对照组的42.86％(15/35)更高,差异有统计学意义(P＜0.05):观察组患者的疾病控制率(DCR)为85.71％(30/35),较对照组的57.14％(20/35)更高,差异有统计学意义(P＜0.05).治疗前,两组患者甲胎蛋白(AFP)水平比较,差异无统计学意义(P＞0.05);治疗后,两组患者AFP水平下降,但观察组较对照组更低,差异有统计学意义(P＜0.05).治疗前,两组患者白蛋白(ALB)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)水平比较,差异无统计学意义(P＞0.05);治疗后,两组患者ALB水平升高,ALT、TBIL水平降低,但观察组患者的上述肝功能指标均较对照组更低,差异有统计学意义(P＜0.05).结论 碳酸氢钠肝动脉灌注联合TACE应用于中晚期HCC患者治疗中,能够提高近期疗效,降低肿瘤标志物水平,改善肝功能指标.
Abstract
Objective To explore the clinical efficacy of sodium bicarbonate hepatic artery infusion combined with hepatic artery chemoembolization(TACE)in the treatment of advanced primary liver cancer(HCC).Methods A total of 70 patients with advanced HCC admitted to the Fifth Affiliated Hospital of Zhengzhou University from December 2020 to January 2023 were selected.Based on the principle of balanced and comparable baseline data between groups,they were randomly divided into an observation group(n=35)and a control group(n=35)using a random number table method.The control group received TACE treatment,while the observation group received sodium bicarbonate hepatic artery infusion combined with TACE treatment.The recent efficacy,tumor markers,and liver function indicators of the two groups of patients were compared and analyzed.Results The objective effective rate(ORR)of the observation group patients was 74.29％(26/35),which was higher than the control group's 42.86％(15/35),and the difference was statistically significant(P＜0.05).The disease control rate(DCR)of the observation group patients was 85.71％(30/35),which was higher than the control group's 57.14％(20/35),and the difference was statistically significant(P＜0.05).Before treatment,there was no statistically significant difference in the levels of alpha fetoprotein(AFP)between the two groups of patients(P＞0.05).After treatment,the AFP levels of the two groups of patients decreased,but the observation group was lower than the control group,and the difference was statistically significant(P＜0.05).Before treatment,there was no statistically significant difference in the levels of albumin(ALB),alanine transferase(ALT),and total bilirubin(TBIL)between the two groups of patients(P＞0.05).After treatment,the levels of ALB increased and the levels of ALT and TBIL decreased in both groups of patients.However,the above liver function indicators in the observation group were lower than those in the control group,and the difference was statistically significant(P＜0.05).Conclusion Sodium bicarbonate hepatic artery infusion combined with TACE can improve short-term efficacy,reduce tumor marker levels,and improve liver function indicators in patients with advanced HCC.
关键词
碳酸氢钠肝动脉灌注/肝动脉化疗栓塞术/中晚期原发性肝癌/临床效果Key words
Sodium bicarbonate hepatic artery perfusion/Hepatoarterial chemoembolization/Middle to late stage primary liver cancer/Clinical effects引用本文复制引用
出版年
2024
NETL
NSTL
万方数据