Objective To investigate the correlation between lipoprotein(a)[Lp(a)]levels and the incidence of acute ST-segment elevation myocardial infarction(STEMI),as well as the impact of Lp(a)on the prognosis of STEMI patients.Methods A total of 72 patients who underwent emergency percutaneous coronary intervention(PCI)for STEMI in the cardiology department of Zibo Municipal Hospital from September 2019 to September 2020 were selected as the STEMI group.During the same period,77 hospitalized patients who underwent coronary angiography to exclude ACS due to acute chest pain were selected as the non ACS group.Baseline data and laboratory tests were compared between the two groups,and multiple logistic regression analysis was used to explore the relationship between Lp(a)and the incidence of STEMI.According to Lp(a)levels,STEMI patients were divided into two subgroups:an elevated Lp(a)group and a normal Lp(a)group.The incidence of complications and major adverse cardiovascular events(MACEs)at 6 months were compared between the two subgroups,and the correlation between Lp(a)levels and STEMI prognosis was analyzed.Results The level of Lp(a)in STEMI group patients was significantly higher than that in non ACS group,and the difference was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that after controlling for factors with poor comparability between groups,Lp(a)levels were still associated with STEMI and were a risk factor for STEMI(OR=3.471,P<0.05).Among STEMI patients,the incidence of complications and 6-month MACE events in the Lp(a)elevated group was significantly higher than that in the Lp(a)normal group,and the difference was statistically significant(P<0.05).Conclusion Elevated levels of Lp(a)are significantly correlated with the onset of STEMI.The level of Lp(a)is significantly correlated with the occurrence and prognosis of complications in STEMI,and may have certain reference value for the risk and prognosis assessment of STEMI patients.
Lipoprotein(a)Acute ST segment elevation myocardial infarctionCorrelationComplicationMajor cardiovascular adverse events
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