经鼻高流量湿化氧疗联合茶碱类药物静脉滴注治疗COPD合并呼吸衰竭的临床效果
Clinical effect of transnasal high-flow humidification oxygen therapy combined with theophylline intravenous infusion in patients with chronic obstructive pulmonary disease complicated with respiratory failure
温春生 1王梓权 1杨文静 1赵雪1
作者信息
- 1. 830000 新疆维吾尔自治区乌鲁木齐市,新疆医科大学第五附属医院呼吸与危重症医学科
- 折叠
摘要
目的 探究经鼻高流量湿化氧疗联合茶碱类药物静脉滴注治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者的临床效果.方法 选取 2022 年 4 月至 2023 年 4 月医院收治的 120 例COPD合并呼吸衰竭患者为研究对象.按照组间基线特征匹配的原则,采用随机数字表法分为对照组 53 例,观察组 67 例.对照组在常规治疗基础上使用无创正压通气联合氨茶碱类药物静脉滴注治疗,观察组在常规治疗基础上采用经鼻高流量湿化氧疗(HFNC)联合氨茶碱类药物静脉滴注治疗.比较两组患者的血气指标、6min步行距离(6MWD)、肺功能指标、血乳酸含量及24h乳酸清除率(LCR).结果 治疗前,两组患者血气指标、6MWD、第 1 秒用力呼吸容积(FEV1)、用力肺活量(FVC)、FEV1/FVC比较,差异无统计学意义(P>0.05);治疗后,两组患者血气指标、6MWD、FEV1、FVC、FEV1/FVC都明显改善,但观察组患者血气指标、6MWD、FEV1、FVC、FEV1/FVC改善程度均优于对照组,差异均有统计学意义(P<0.05).治疗前,两组患者血乳酸含量比较,差异无统计学意义(P>0.05);治疗24h后,两组患者血乳酸含量均降低,但观察组患者血乳酸含量低于对照组,差异有统计学意义(P<0.05).观察组患者 24hLCR高于对照组,差异有统计学意义(P<0.05).结论 经鼻高流量湿化氧疗联合茶碱类药物静脉滴注可改善COPD合并呼吸衰竭患者呼吸力学及肺功能,有效提高患者LCR,减少疾病对生活的影响,促进患者康复.
Abstract
Objective To explore the clinical effect of transnasal high-flow humidification oxygen therapy combined with theophylline intravenous infusion in patients with chronic obstructive pulmonary disease(COPD)combined with respiratory failure.Methods A total of 120 COPD patients with respiratory failure admitted to the hospital from April 2022 to April 2023 were selected.According to the random number table method,53 cases were divided into the control group and 67 cases in the observation group.The control group used non-invasive positive pressure ventilation combined with aminophylline intravenous infusion on the basis of conventional therapy,and the observation group used high-flow humidification oxygen therapy(HFNC)combined with aminophylline intravenous infusion on the basis of conventional therapy.Blood gas index,6min walking distance(6 MWD),pulmonary function index,blood lactate content and 24h lactate clearance(LCR)were compared.Results Before treatment,there were no statistically significant differences between 6 MWD,FEV1,FVC,FEV1/FVC(P>0.05);respectively,6 MWD,FEV1,FVC,FV1,FV1/FVC improved over the control groups,which were statistically significant(P<0.05).Before treatment,no difference between the two groups(P>0.05);After 24h of intravenous infusion with HFNC and aminophylline,the two groups decreased,but the observation group was lower than that of the control group(P<0.05).The 24-h LCR in the observation group was higher than that in the control group,which was significant(P<0.05).Conclusion Transnasal high-flow humidification oxygen therapy combined with theophylline intravenous infusion can improve the respiratory mechanics and lung function in COPD patients with respiratory failure,effectively improve the LCR,reduce the impact of disease on life,and promote the recovery of patients.
关键词
慢性阻塞性肺疾病/经鼻高流量湿化氧疗/茶碱类药物/乳酸清除率Key words
Chronic obstructive pulmonary disease/High-flow respiratory humidification therapy instrument/Theophylline-based drugs/Lactate clearance rate引用本文复制引用
出版年
2024
NETL
NSTL
万方数据