针刺内关、百会、四神聪穴对脑卒中后认知障碍及脑网络属性的影响
Effects of acupuncture at Neiguan,Baihui and Sishencong on the cognitive impairment and brain network properties after stroke
肖伟 1余巨明1
作者信息
- 1. 637000 四川省南充市,川北医学院附属医院
- 折叠
摘要
目的 评估针刺内关、百会、四神聪穴对卒中后认知障碍(PSCI)患者认知情况的影响,同时探讨针刺干预后PSCI患者的脑网络变化特征.方法 选取川北医学院附属医院神经内科住院治疗的30名PSCI患者为研究对象,按随机数字表,结合组间性别、年龄、单/双抗、汉密尔顿抑郁量表、危险因素个数均衡可比的原则,分为观察组20例和对照组10例.观察组针刺内关、百会、四神聪穴治疗,对照组针刺相应穴位旁治疗.比较两组患者简易精神状态评价量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分及脑网络属性的改变.结果 治疗后,两组患者的MMSE、MoCA评分均明显升高,但观察组患者治疗后MMSE、MoCA评分升高的幅度大于对照组,差异有统计学意义(P＜0.05).节点属性发现观察组患者认知相关脑区(左海马旁回、左侧后扣带回、左梭状回、左枕下回等)的度中心性增高,此外,Pearson相关分析发现左枕下回的度中心性与MoCA量表评分呈相关.结论 针刺内关、百会、四神聪疗法能改善PSCI患者的认知功能,其改善作用可能与认知相关脑区度中心性改变有关,其对于临床的疗效是积极的,值得进一步探索.
Abstract
Objective To evaluate the effects of acupuncture at Neiguan,Baihui and Sishencong on the cognitive status of patients with post-stroke cognitive impairment(PSCI),and to explore the characteristics of brain network changes in patients with PSCI after acupuncture intervention,and to determine the therapeutic effect and possible brain mechanism of acupuncture therapy on PSCI.Methods Thirty patients with PSCI who were hospitalized in the Department of Neurology of the Affiliated Hospital of North Sichuan Medical College were selected as the study objects,and were divided into the observation group(20 cases)and the control group(10 cases)according to the principle of gender,age,single/double antibody,Hamilton depression Scale and the number of risk factors.The observation group was treated with acupuncture at Neiguan,Baihui and Sishencong points,while the control group was treated with acupuncture at corresponding acupoints.The scores of MMSE and Montreal Cognitive Assessment Scale(MoCA)and the changes of brain network attributes were compared between the two groups.Results Compared with control group,MMSE and MoCA scores in observation group were significantly different before and after treatment(P＜0.05).The difference of MMSE and MoCA between observation group and control group was statistically significant(P＜0.05).Node attributes found that degree centrality of cognitively related brain areas(left parahippocampal gyrus,left posterior cingulate gyrus,left fusiform gyrus,left suboccipital gyrus,etc.)increased in the observation group.In addition,Pearson correlation analysis found that degree centrality of left suboccipital gyrus was correlated with MoCA scale scores.Conclusion Acupuncture therapy of Neiguan,Baihui and Sishencong can better improve the cognitive function of PSCI patients,and its improvement effect may be related to the change of the degree centrality of cognition-related brain areas.Its clinical effect is positive and worthy of further exploration.
关键词
针刺/脑卒中/认知障碍/脑网络属性Key words
Prick/Stroke/Cognitive impairment/Brain network properties引用本文复制引用
基金项目
2022年川北医学院附属医院科研项目(2022LC019)
出版年
2024
NETL
NSTL
万方数据