Objective To explore the association of peripheral blood thymus activation-regulated chemokine(TARC),vascular cell adhesion molecule-1(VCAM-1),and serum amyloid A(SAA)with ventilator-associated pneumonia(VAP)in Gram-negative bacteria infection.Methods Taking the children with respiratory dysfunction(all on ventilators)treated in hospital from March 2022 to March 2023 as the study subjects,56 children with gram-negative VAP were selected as the case group and 52 children without gram-negative VAP were selected as the control group.Serum levels of TARC,VCAM-1,and SAA were tested and compared in the two groups.Compared severe(n=19)and mild(n=37)in children with infection.The correlation of the above indexes with VAP infection with gram-negative bacteria was analyzed by Logistic regression model.Results The serum levels of TARC,VCAM-1 and SAA were higher than those of the control group,statistically significant(P＜0.05);the serum levels of TARC,VCAM-1 and SAA in the severe case group were higher than those of the mild case group(P＜0.05).Multivariate Logistic regression analysis found that high levels of TARC,VCAM-1,and SAA were risk factors for gram-negative bacteria VAP after mechanical ventilation(P＜0.05).The ROC curve results showed that the AUC of TARC,VCAM-1 and SAA were＞0.50(P＜0.05),indicating that the three indicators had the efficacy of gram-negative bacteria infection with VAP,but the sensitivity was＜70％,and the clinical application effect was general.Conclusion Serum expressions of TARC,VCAM-1,and SAA were significantly upregulated in children infected with Gram-negative bacteria,and high levels of TARC,VCAM-1,and SAA were high risk factors for VAP infection of gram-negative bacteria after mechanical ventilation.All three indicators had differential diagnostic efficacy,but the effect was general.
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