冠心病患者入院体重指数与静息心率的关系研究
Relationship between body mass index and resting heart rate at admission in patients with coronary heart disease
黄琼芳 1潘燕彬 1颜建龙2
作者信息
- 1. 深圳市人民医院/暨南大学第二临床医学院/南方科技大学第一附属医院健康管理科,广东深圳 518020
- 2. 深圳市人民医院/暨南大学第二临床医学院/南方科技大学第一附属医院心血管内科/深圳市心血管微创医学工程技术研究开发中心,广东 深圳 518020
- 折叠
摘要
目的 评估冠心病患者入院体重指数(BMI)与静息心率(RHR)的关系.方法 收集深圳市人民医院2018年1月至2021年12月2 533例冠心病患者的原始数据.排除BMI(n=914)、入院时RHR(n=155)变量数据缺失及其他协变量缺失资料(n=122)的患者,最终纳入1 342例冠心病患者.采用单变量和多变量回归模型评价BMI和RHR之间的关系,为了确定BMI和RHR之间的关联,进行分层分析和交互检验,最后通过调整潜在混杂因素后的平滑曲线拟合探讨BMI和RHR之间的关系.结果 BMI与入院时的RHR呈负相关(校正后的β=-0.50,95％CI-0.67～-0.33,P＜0.001).以BMI的最低组作为参考,RHR随着BMI 的增加而下降(β=-1.96,95％CI-3.55～-0.37,P=0.016;β=-3.45,95％CI-5.13 1.76,P＜0.001;β=-5.35,95％CI-7.13～-3.57,P＜0.001),趋势性检验 P＜0.001.然而,BMI 和 RHR 之间存在非线性关系.BMI＜27.6 kg/m2 调整后的回归系数为-0.70(95％CI-0.93～-0.48,P＜0.001),而 BMI≥27.6 kg/m2则为0.11(95％CI-0.37～0.59,P=0.649).结论 在冠心病患者入院时,BMI与RHR呈显著负相关,存在饱和效应.
Abstract
Objective To assess the relationship between the body mass index(BMI)and the resting heart rate(RHR)at admission in the patients with coronary heart disease(CHD).Methods The original da-ta of 2 533 patients with CHD in Shenzhen Municipal People's Hospital.The univariate and multivariate re-gression models were used to evaluate the relationship between BMI and RHR,and in order to determine the association between BMI and RHR,the stratified analysis and interaction tests were conducted.Lastly,the re-lationship between BMI and RHR was investigated by the smooth curve fitting after adjusting the potential confounding factors.Results BMI was negatively correlated with RHR at admission(adjusted β=-0.50,95％CI-0.67--0.33,P＜0.001).Using the lowest group of BMI as the reference,RHR was decreased with the increase of BMI(a=-1.96,95％CI-3.55--0.37,P=0.016;β=-3.45,95％CI-5.13--1.76,P＜0.001,and β=-5.35,95％CI-7.13--3.57,P＜0.001),trend test P＜0.001.However,a nonlinear relationship existed between BMI and RHR.The regression coefficient was-0.70(95％CI-0.93--0.48,P＜0.001)after BMI＜27.6 kg/m2 adjustment,while which was 0.11(95％CJ-0.37-0.59,P=0.649)for BMI ≥27.6 kg/m2.Conclusion BMI has significantly negative correlation with RHR at admission in the patients with CHD,and the saturation effect exists.
关键词
体重指数/肥胖/心率/冠心病Key words
Body mass index/Obesity/Heart rate/Coronary heart disease引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据