首页|结直肠癌预后和血小板参数相关性的meta分析

结直肠癌预后和血小板参数相关性的meta分析

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目的 系统评价结直肠癌(CRC)预后和平均血小板体积(MPV)、血小板计数(PLT)与血小板体积分布宽度(PDW)指标相关性.方法 检索从建库到2021年6月在Embase、PubMed、Cochrane Library、Web of Science、中国万方、知网、中国生物医学文献与维普数据库发表的关于MPV、PLT、PDW指标和CRC预后相关性的研究.按照纳入与排除标准筛选文献,并提取相关数据,使用Review Manager 5.3软件进行me-ta分析.结果 初步检索共得到546篇文献,在剔除阅读文献题目、重复研究、病例报道和文献综述后,最终10篇文章纳入研究,根据meta分析结果,MPV指标上升和CRC患者总生存期(OS)预后不良无关(单因素分析法HR=0.94,95%CI 0.48~1.81,P=0.85,I2=85%);PLT指标上升是CRC患者OS预后不良的危险因素(单因素分析法 HR=1.60,95%CI 1.22~2.10,P<0.001,I2=63%);PDW 指标上升和 CRC 患者 OS 预后不良无关(单因素分析法HR=1.34,95%CI 0.31~5.88,P=0.70,I2=93%).单因素合并MPV效应量和CRC预后关系的研究中,漏斗图基本对称,没有发现显著的发表偏倚.PLT效应量和CRC预后关系的漏斗图显示基本对称,没有发现显著的发表偏倚.同时单因素合并PDW效应量和CRC预后关系研究分析漏斗图基本对称.结论 PLT指标升高是CRC预后不良的危险因素,但尚未发现PDW、MPV上升对CRC患者预后不良的预测价值.
Meta analysis of correlation between colorectal cancer prognosis and PLT indexes
Objective To systematicaly evaluate the correlation between the colorectal cancer(CRC)prognosis with mean platelet volume(MPV),platelet count(PLT)and platelet volume distribution width(PDW).Methods The studies on the correlation between MPV,PLT and PDW indexes with the CRC prog-nosis published in the Embase,PubMed,Cochrane Library,Web of Science,China Wanfang,CNKI,Chinese Bi-omedical Literature and VIP from the establishment of the database to June 2021 were retrieved.The litera-tures were screened according to the inclusion and exclusion criteria,and relevant data were extracted.Then the meta analysis was performed by using Review Manager 5.3 software.Results A total of 546 articles were obtained by the preliminary retrieval.After removing the reading literature titles,duplicate studies,case re-ports and literature reviews,10 articles were finally included in the study.According to the meta analysis re-sults,the increase of MPV index was not related with the overall survival(OS)in the patients with colorectal cancer(single factor analysis method,HR=0.94,95%CI 0.48-1.81,P=0.85,I2=85%);the PLT index increase was a risk factor for poor prognosis of OS in the patients with colorectal cancer(univariate analysis method:HR=1.60,95%CI 1.22-2.10,P<0.001,I2=63%);the increase of PDW index was not related with poor OS prognosis in the patients with colorectal cancer(univariate analysis method:HR=1.34,95%CI 0.31-5.88,P=0.70,I2=93%).In the study of the relationship between univariate combined MPV effect size and colorectal cancer prognosis,the funnel plot was basically symmetrical,and no significant publication bias was found.The funnel plot of the relationship between PLT effect size and colorectal cancer prognosis showed substantial symmetry and no significant publication bias was found.At the same time,the funnel plot of the relationship between univariate combined PDW effect size and colorectal cancer prognosis was basically symmetrical.Conclusion The PLT index increase is a risk factor for poor prognosis of CRC,but the predictive value of PDW and MPV increase for the poor prognosis of the patients with colorectal cancer has not been found.

Colorectal cancerMean platelet volumePlatelet countPlatelet volume distribution widthMeta analysis

魏望、陆丹、孙静芳

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邳州市人民医院检验科,江苏 邳州 221300

徐州医科大学附属医院检验科,江苏 徐州 221002

结直肠癌 平均血小板体积 血小板计数 血小板体积分布宽度 meta分析

江苏省徐州市卫生健康委青年医学科技创新项目

XWKYHT20220160

2024

现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子:0.758
ISSN:1009-5519
年,卷(期):2024.40(1)
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