首页|子宫内膜癌TCGA分子分型与患者FIGO分级和分期关系的meta分析

子宫内膜癌TCGA分子分型与患者FIGO分级和分期关系的meta分析

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目的 评估子宫内膜癌TCGA分子分型与患者FIGO分级和临床分期的关系.方法 计算机检索PubMed、Web of Science、Embase、中国知网、万方数据库关于子宫内膜癌TCGA分子分型的临床研究,检索时限为建库至2021年12月,根据纳入和排除标准筛选文献,进行资料提取.采用RevMan 5.3和SPSS 21.0软件对纳入文献进行meta分析.结果 共纳入10篇相关文献,其中英文文献6篇,中文文献4篇.共有3 813例子宫内膜癌患者,其中POLE突变型213例(5.6%),MSI-H型1 103例(28.9%),CN-L型1 954例(51.2%),CN-H型543例(14.2%).10篇文献均分析了 TCGA分子分型与FIGO分级的关系,8篇文献分析了与临床分期、肌层浸润深度、淋巴结转移的关系,9篇文献分析了与组织学分型及LVSI的关系,2篇文献分析了与腹腔冲洗液细胞学的关系.FIGO G3级与G1~2级相比较,POLE突变型OR=1.46(95%CI 1.06~2.03);MSI-H 型 OR=1.42(95%CI 1.16~1.74);CN-L 型 OR=0.20(95%CI 0.14~0.29);CN-H 型 OR=9.62(95%CI 4.61~16.67).FIGO Ⅱ~Ⅳ 期与 FIGO Ⅰ 期相比较,POLE 突变型 OR=0.44(95%CI 0.27~0.72);MSI-H 型 OR=1.12(95%CI 0.92~1.37);CN-L 型 OR=0.51(95%CI 0.36~0.74);CN-H 型OR=2.81(95%CI 2.23~3.53).结论 FIGO G3级及Ⅰ期子宫内膜癌患者更容易发生POLE突变,FIGO G3级及Ⅱ~Ⅳ期患者更容易发生高拷贝数变异,临床病理特征需结合分子分型指导患者预后及治疗.
Relationship between TCGA molecular classification with FIGO grade and stage of endometrial cancer:a meta analysis
Objective To evaluate the relationship between TCGA molecular typing with FIGO grade and clinical stage of endometrial carcinoma.Methods The clinical studies about TCGA molecular typing of endometrial cancer in PubMed,Web of Science,EMBASE,CNKI and Wanfang databases were retrieved by computer.The retrival time was from the establishment of the database to December 2021.The literatures were screened according to the inclusion and exclusion criteria for conducting the data extraction.The RevMan 5.3 and SPSS 21.0 softwares were used for the meta analysis.Results A total of 10 related articles were in-cluded,6 articles in English and 4 articles literatures in Chinese.There were 3 813 cases of endometrial cancer,including 213 cases(5.6%)of POLE mutation type,1 103 cases(28.9%)of MSI-H type,1 954 cases(51.2%)of CN-L type and 543 cases(14.2%)of CN-H type.A total of 10 articles analyzed the relationship between TCGA molecular subgroups and FIGO grade,8 articles analyzed the relationship with the clinical stage,depth of muscular infiltration and lymph node metastasis,9 articles analyzed the relationship with the histological typing and LVSI,and 2 articles analyzed the cytological statistics of peritoneal lavage fluid.In the comparison between FIGO G3 and G1-2 stage,OR of POLE mutant type was 1.46(95%CI 1.06-2.03);OR of MSI-H type was 1.42(95%CI 1.16-1.74);OR of CN-L type was 0.20(95%CI 0.14-0.29);OR of CN-H type was 9.62(95%CI 4.61-16.67).In the comparision between FIGO Ⅱ-Ⅳ and FIGO 1,OR of POLE mutant type was 0.44(95%CI 0.27-0.72);OR of MSI-H type was 1.12(95%CI 0.92-1.37;OR of CN-L type was 0.51(95%CI 0.36-0.74;OR of CN-H type was 2.81(95%CI 2.23-3.53).Conclusion The patients with FIGO G3 grade and FIGO stage I endometrial cancer are more likely to develop POLE mutation,and the patients with FIGO G3 grade and Ⅱ-Ⅳ stage are more likely to develop high copy number variation.Clinicopathological features should be combined with molecular type to guide the prognosis and treatment of the patients.

Endometrial carcinomaTCGA molecular classificationFIGO gradeClinical stageMeta analysis

闫广伟、张佩、谢祎飞、郭永真、曾宪旭

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郑州大学第三附属医院病理科,河南 郑州 450052

子宫内膜癌 TCGA分子分型 FIGO分级 临床分期 meta分析

河南省医学科技攻关计划项目

LHGJ20210436

2024

现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子:0.758
ISSN:1009-5519
年,卷(期):2024.40(1)
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