目的 探讨2型糖尿病合并糖尿病周围神经病变(DPN)与糖尿病肾病、下肢动脉粥样硬化症的相关性。方法 选取2020年1-12月在该院内分泌科住院的T2DM患者298例，根据患者是否合并DPN分为DPN组(178例)和非DPN组(120例)。比较2组随机尿白蛋白/肌酐比值(UACR)、空腹血糖(FBS)、餐后2 h C肽(2 h CP)水平及下肢动脉粥样硬化症、糖尿病肾病发生率等指标，同时分析DPN的独立危险因素。结果 2组年龄、性别、病程及随机UACR、FBS、2 h CP水平比较，差异有统计学意义(P＜0。05)，而其余指标比较，差异无统计学意义(P＞0。05)。2组下肢动脉粥样硬化症及糖尿病肾病发生率比较，差异有统计学意义(P＜0。05)。下肢动脉粥样硬化症、糖尿病肾病是DPN的独立危险因素(P＜0。05)。结论 DPN与糖尿病肾病、下肢动脉粥样硬化症显著相关。
Correlation between type 2 diabetes with DPN and diabetic nephropathy,lower extremity atherosclerosis
Objective To explore the relationship between type 2 diabetes with diabetic peripheral neu-ropathy(DPN),diabetes nephropathy,and lower extremity atherosclerosis.Methods A total of 298 T2DM pa-tients admitted to the Department of Endocrinology of our hospital from January to December 2020 were se-lected and divided into the DPN group(178 cases)and the non-DPN group(120 cases)according to whether combined with DPN.The levels of random urinary albumin/creatinine ratio(UACR),fasting blood sugar(FBS),2-hour postprandial C-petide(2 h CP)and the incidence of lower limb atherosclerosis and diabetic ne-phropathy were compared between the two groups,and the independent risk factors of DPN were analyzed.Results There were statistically significant differences in age,gender,course of disease and random UACR,FBS and 2 h CP levels between the two groups(P＜0.05),while there were no statistically significant differ-ences in other indicators(P＞0.05).The incidence of lower extremity atherosclerosis and diabetic nephropathy between two groups was statistically significant(P＜0.05).Lower extremity atherosclerosis and diabetic ne-phropathy were independent risk factors for DPN(P＜0.05).Conclusion DPN is significantly correlated with diabetes nephropathy and lower limb atherosclerosis.
Type 2 diabetesPeripheral neuropathyLower limb atherosclerosisDiabetes ne-phropathy
万方数据
维普
