Expression of ISG15 protein in primary hepatocellular carcinoma and its prognostic impact
Objective To explore the expression level and clinical prognostic value of interferon stimu-lated gene 15(ISG15)protein in primary hepatocellular carcinoma(HCC).Methods A total of 100 HCC pa-tients confirmed by postoperative pathology in the hospital from January 2018 to October 2020 were selected,and di-vide into the low expression group and the high expression group based on the ISG15 protein expression level.The ex-pression levels of ISG15 protein in patients with different clinical characteristics were compared,and the survival status of patients with different levels of ISG15 protein expression were analyzed.Results The expression levels of ISG15 protein in cancer tissue and adjacent tissues were(5.00±1.69)and(3.78±1.22),respectively,and the differ-ence between the two tissue was statistically significant(t=5.766,P＜0.001).There was statistically signifi-cant difference in the expression level of ISG15 protein among patients with different tumor sizes,HBV-DNA copy numbers,and differentiation levels(P＜0.05).The median survival time of the low expression group was 40.5 months,with a survival rate of 70.83％,while the median survival time of the high expression group was 33.0 months,with a survival rate of 24.39％.The difference between the two groups was statistically signifi-cant(x2=9.980,P=0.001 6).Conclusion ISG15 protein is highly expressed in HCC cancer tissue and plays a related role in inhibiting tumor cell growth,resisting HBV virus replication,and inhibiting cancer cell differ-entiation.The expression of ISG15 protein is related to clinical prognosis,and those with low expression have a longer survival period.
万方数据
维普
