Application of different doses of dexmedetomidine assisted thoracic paravertebral block in cardiac surgery
Objective To explore the application effect of different doses of dexmedetomidine assisted thoracic paravertebral block(TPVB)in cardiac surgery.Methods A total of 80 patients who underwent off-pump coronary artery bypass grafting(OPCABG)in the hospital from January 2022 to January 2023 were ran-domly divided into the 0.25 μg/kg dexmedetomidine group(Group A),the 0.50 μg/kg dexmedetomidine group(Group B),the 1.00 μg/kg dexmedetomidine group(Group C)and the placebo group(Group D),with 20 cases in each group.The levels of cortisol(Cor),interleukin-6(IL-6),visual analogue scale(VAS)score,inten-sive care unit(ICU)stay time,postoperative mechanical ventilation time,and postoperative hospital stay in each group were compared.Results There were no statistically significant differences in the levels of Cor and IL-6 between the four groups before anesthesia induction and 24 hours after surgery(P＞0.05).The levels of Cor and IL-6 at 2 hours after the start of surgery,immediately after surgery,and 24 hours after surgery in the four groups were higher than those before anesthesia induction,and the differences were statistically signifi-cant(P＜0.05).The levels of Cor and IL-6 in groups B and Cwere lower than those in groups A and D at 2 hours after the start of surgery and immediately after surgery,and the differences were statistically significant(P＜0.05).There was statistically significant difference in VAS scores immediately after extubation and 12 hours after surgery among the four groups,with groups B and C having lower VAS scores than groups A and D(P＜0.05).There was no statistically significant difference in VAS scores at 24 hours after surgery among the four groups(P＞0.05).There were no statistically significant differences in VAS scores at different time points in each group(P＞0.05).There were no statistically significant differences in ICU stay time,postopera-tive mechanical ventilation time,and postoperative hospitalization time among the four groups(P＞0.05).Conclusion Dexmedetomidine assisted TPVB can inhibit the perioperative stress response of OPCABG,improve the postoperative pain,and 0.50 μg/kg dexmedetomidine is recommended as an adjuvant dose for TPVB.
万方数据
维普
