Chronic kidney disease(CKD)refers to chronic kidney structure and dys-function caused by various reasons,and renal fibrosis is one of its common pathological ma-nifestations,mainly including the en-tire process of renal function from damage to complete loss.Long noncoding RNA(lncRNA),as a type of non protein coding RNA,has a wide variety of types and is widely involved in various cellular biological regulatory processes in the body.It can regulate microRNAs activity,control the expression of target genes,and partici-pate in the occurrence and evolution of various diseases,including CKD.The occurrence of chronic kidney dis-eases such as diabetes nephropathy,obstructive nephropathy and lupus nephritis is related to renal fibrosis,and is closely related to a variety of lncRNA and corresponding molecular signal pathways.This provides some safer and more reliable new treatment ap-proaches for the prevention and treatment of CKD.
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