Pulmonary arterial hypertension(PAH)is a serious pulmonary vascular disease that poses a threat to human health,ultimately leading to pulmonary vascular remodeling and right ventricular dysfunc-tion.At present,the pathogenic mechanism of PAH has not been elucidated.The pathophysiology of PAH is complex and variable,with complex intersections between various signaling pathways such as nitric oxide,prostacyclin,and neurohumoral and hormonal pathways.Mitochondrial related metabolic dysregulation,envi-ronmental and inflammatory damage are also involved.The article reviews the research progress on the patho-logical mechanism of PAH.
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