Clinical and pathological features of renal collecting duct carcinoma:a study of 10 cases
Objective To investigate the clinical and pathological features of renal collecting duct carci-noma(CDC).Methods Clinical and pathological data of the 10 CDC patients diagnosed from 2017 to 2023 in this hospital were collected,followed up and relevant literatures were reviewed.Results The clinical symp-toms of the 10 CDC patients were non-specific,mainly hematuria and lower back pain,and some were accom-panied by frequent urination,urgency,and increased nocturia;The tumors of five cases were located in the left kidney and the others were located in the right kidney;All the 10 cases underwent radical nephrectomy.Histo-logically,the tumor underwent infiltrative growth,with tumor cells arranged in tubular,papillary,nested,or solid patches,or in a sarcomatoid manner.Some tumor cells within the lumen protruded into the glandular cavity in a shoe like manner;Tumor cells had high-grade differentiated nuclei,obvious cell abnormalities,large nuclei,prominent nucleoli,and mitotic figures were easily visible;Interstitial fibrous tissue hyperplasia was with significant infiltration of inflammatory cells;Tumor necrosis was seen in most cases.Immunohistochemi-cal results showed positive expression of CK,CK7,CK19,Pax-8,and Vimentin,EMA,34βE12 and CarbonicaⅨ were positive to varying degrees,while RCC,CD10,CD117,TFE3,TFEB,P504S,and CK20 were all nega-tive;The proliferation index of Ki-67 was 20％-70％.Seven cases were followed up,and three cases were lost;At the date of the last follow-up,only one case survived,and six cases all died within two years.Conclu-sion CDC is a very rare renal epithelial malignancy with high malignancy,rapid progression,and poor prog-nosis.
万方数据
维普
