现代医药卫生2024,Vol.40Issue(3) :436-440.DOI:10.3969/j.issn.1009-5519.2024.03.016

载脂蛋白B与急性冠状动脉综合征的相关性研究进展

Apolipoprotein B and acute coronary syndrome:a review

郑怡雯 黄晶
现代医药卫生2024,Vol.40Issue(3) :436-440.DOI:10.3969/j.issn.1009-5519.2024.03.016

载脂蛋白B与急性冠状动脉综合征的相关性研究进展

Apolipoprotein B and acute coronary syndrome:a review

郑怡雯 1黄晶1
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作者信息

  • 1. 重庆医科大学附属第二医院心血管内科,重庆 400010
  • 折叠

摘要

载脂蛋白B是直接参与动脉粥样硬化过程的重要蛋白质,与心血管事件发生密切相关.急性冠状动脉综合征是以冠状动脉粥样硬化斑块破裂,继而发生完全或不完全闭塞性血栓形成引发心肌急性缺血或坏死为病理基础的临床综合征.研究表明载脂蛋白B能更全面涵盖致动脉粥样硬化颗粒,有望成为预测急性冠状动脉综合风险及预后的有力指标.该文综述了载脂蛋白B的结构、参与急性冠状动脉综合征发生发展的机制及过程、相应预防、治疗及研究进展.

Abstract

Apolipoprotein B is an important protein directly involved in the atherosclerotic process and is closely related to the occurrence of cardiovascular events.Acute coronary syndrome is a clinical syndrome based pathologically on the rupture of a coronary atherosclerotic plaque followed by complete or incomplete occlusive thrombosis triggering acute ischemia or necrosis of the myocardium.Studies have shown a more comprehensive coverage of atherogenic particles by apolipoprotein B,which is expected to be a powerful pre-dictor of acute coronary syndrome risk and prognosis.In this review,we summarize the structure of apoB,the mechanisms and processes involved in the development and progression of ACS,the corresponding prevention,treatment,and research.

关键词

载脂蛋白B/急性冠状动脉综合征/动脉粥样硬化/综述

Key words

Apolipoprotein B/Acute coronary syndrome/Atherosclerotic/Review

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基金项目

国家自然科学基金面上项目(82170445)

出版年

2024
现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子:0.758
ISSN:1009-5519
参考文献量36
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