Refractory asthma in children seriously affects their lung function and quality of life.There are no guidelines for the diagnosis and treatment of refractory asthma in children in China.This article reviews the research progress on childhood refractory asthma in terms of genetic,environmental,socio-psychological factors.Through genetic testing and biological indicators,early identification of refractory asthma in children and individualized treatment based on molecular level,combined with the control of environmental factors and psychosocial factors,provide new ideas for the prevention and control of refractory asthma in children.
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