Annexin(ANX)are a family of intracellular proteins that bind membrane phospholipids in a calcium ion(Ca2+)-concentration-dependent manner and are widely expressed in various cell types.ANXA11 is a member of the Ca2+-regulated phospholipid-dependent and membrane-bound ANX multigene family.Previ-ous studies have shown that ANXA11 has important roles in cell division,Ca2+ signaling,vesicle trafficking,and apoptosis.Recent studies have shown that dysregulation and mutation of ANXA11 are associated with the development of systemic autoimmune diseases and cancers,chemotherapy resistance,and recurrence,etc.ANXA11,which is highly expressed in a variety of tumors,can be involved in tumorigenesis and development as a pro-carcinogenic gene,and is expected to be a potential molecular marker for cancer diagnosis,treatment,and prognosis.This article reviews the biological function and the research progress of ANXA11 in tumors in recent years.
万方数据
维普
