Value analysis of ultrasonic parameters combined with peripheral blood indexes in the diagnosis of lymphoma in children
Objective To investigate the diagnostic value of ultrasound parameters combined with pe-ripheral blood indexes in childhood with lymphoma.Methods A total of 123 children with enlarged superficial lymph nodes suspected as lymphoma admitted to this hospital from June 2018 to October 2020 were examined by ultrasound.Among them,85 children were pathologically diagnosed as lymphoma(the lymphoma group),38 children were diagnosed as benign lesions(the benign group),and 30 healthy children were collected as the healthy group.The diagnostic value of the ultrasonic parameters such as length-to-short diameter ratio(L/S),lymphatic hilum and blood flow type were evaluated in children with non-Hodgkin lymphoma.The expression of three immune-related genes,CC chemokine receptor 5(CCR5),programmed cell death protein 1(PD-1)and fork head box P3(FOXP3)in peripheral blood of children with lymphoma was analyzed by reverse transcrip-tion-polymerase chain reaction,and the combined diagnostic value of ultrasound parameters combined with three peripheral blood indexes in the childhood lymphoma was analyzed.Results The area under curve(AUC),sensitivity and specificity of L/S,lymphatic hilum and blood flow types in the combined diagnosis of lymphoma were 0.846,89.41％and 68.42％,respectively.The relative expression of CCR5,PD-1 and FOXP3 mRNA in peripheral blood of children in lymphoma group was significantly higher than those in healthy group and benign group,and the difference was statistically significant(P＜0.05).The AUC,sensitivity and specific-ity of ultrasound parameters combined with peripheral blood CCR5,PD-1 and FOXP3 in the diagnosis of lym-phoma were 0.976,97.65％and 92.11％,respectively.Conclusion Ultrasound parameters(L/S,lymphatic hi-lum,and blood flow type)combined with peripheral blood CCR5,PD-1,and FOXP3 have a very high diagnos-tic value for lymphoma.
Non-Hodgkin's lymphomaChildrenUltrasonographyPeripheral bloodDiag-nostic value
万方数据
维普
