Correlation between heart failure and intestinal flora imbalance in elderly COPD patients
Objective To study the correlation between heart failure and intestinal flora imbalance in elderly patients with chronic obstructive pulmonary disease(COPD).Methods A total of 149 elderly patients with COPD admitted to the Second Affiliated Hospital of Zhengzhou University from January 2020 to January 2023 were selected as the research objects.According to whether heart failure occurred,they were divided into study group(heart failure,60 cases)and control group(no heart failure,89 cases).The general data and the number of intestinal flora of the two groups were compared,and the influencing factors of heart failure in eld-erly patients with COPD were analyzed by multivariate logistic regression model.The number of intestinal flo-ra in COPD patients with heart failure of different New York Heart Association(NYHA)grades was com-pared.Results Among the 149 patients,60 were complicated with heart failure,with an incidence of 40.27％.There was no significant difference in gender,age,body mass index and other general data between the two groups(P＞0.05).The number of Bifidobacterium,Lactobacillus and Bacteroides in the study group was sig-nificantly less than that in the control group,and the number of Escherichia coli and yeast-like fungi was sig-nificantly more than that in the control group,the differences were statistically significant(P＜0.05).Esche-richia coli and yeast-like fungi were risk factors for heart failure in elderly patients with COPD,and bifidobac-terium,lactobacillus and bacteroides were protective factors for heart failure in elderly patients with COPD,with statistically significant differences(P＜0.05).The number of bifidobacterium,Lactobacillus and Bacte-roides in patients with NYHA grade Ⅲ-Ⅳ COPD and heart failure was significantly less than that in patients with grade Ⅰ-Ⅱ,and the number of escherichia coli and yeast-like fungi was significantly more than that in patients with grade Ⅰ-Ⅱ,the differences were statistically significant(P＜0.05).Conclusion There is a certain risk of heart failure in elderly patients with COPD,and the imbalance of intestinal flora will increase the above risks,which is closely related to the degree of cardiac function damage.
Chronic obstructive pulmonary diseaseHeart failureThe elderlyGastrointestinal tractBacteriaCorrelation study
万方数据
维普
