Risk factors for recurrent acute pancreatitis in Chinese population:a meta-analysis
Objective To systematically evaluate the characteristics of the severity,risk factors,and eti-ology of recurrent acute pancreatitis(RAP)in the Chinese population.Methods The PubMed,Web of Sci-ence,Embase,China national knowledge internet(CNKI),Wanfang Data,VIP and other databases were searched computationally for case-control studies and cohort studies on risk factors for RAP.The retrieval time was from the establishment of the database to April 1,2022,and meta-analysis was conducted by using RevMan5.3 software.Results A total of 21 studies were included,including 20 case-control and one cohort study.The proportion of severe RAP patients was significantly higher than that of acute pancreatitis patients,and the difference was statistically significant(OR=1.70,95％CI:1.09-2.66,P=0.020 00).Smoking(OR=2.10,95％CI:1.11-4.00,P=0.020 00)and diabetes mellitus(OR=2.45,95％CI:1.50-4.01,P=0.000 40)were significant risk factors for RAP,while hypertension(OR=0.72,95％CI:0.59-0.88,P=0.001 00)was not a risk factor of RAP,and the differences were statistically significant.Hyperlipidemic AP(OR=2.27,95％CI:1.80-2.88,P＜0.000 10),alcoholic AP(OR=1.31,95％CI:1.04-1.67,P＜0.020 00),combined AP(OR=1.46,95％CI:1.06-2.02,P＜0.020 00)had higher hazard ratios for recur-rence,while biliary(OR=0.71,95％CI:0.51-0.98,P＜0.040 00)and idiopathic(OR=0.65,95％CI:0.44-0.98,P＜0.040 00)were the protective factors of RAP,and the differences were statistically significant.Con-clusion Smoking and diabetes are still risk factors for RAP in the Chinese population,whereas alcoholic AP,hyperlipidemic AP,and combined AP are the major types of the etiology of RAP.
万方数据
维普
