Gelsolin(GSN)is a multifunctional actin-binding protein that affects the biological activity of tumor cells by regulating actin cytoskeleton reorganization and extracellular matrix remodeling.The expres-sion and deletion of GSN exhibit a bidirectional effect on various tumors.GSN can enhance the proliferation,migration,and invasion of tumor cells in multiple cancer types,thereby promoting tumor occurrence and me-tastasis.And reversing GSN expression can suppress the malignant behavior of tumor cells.Furthermore,GSN exhibits the potential to serve as a diagnostic marker for diverse types of cancer and may function as a genetic signature to forecast the prognosis of individuals with tumors.This article reviewed the bidirectional regulato-ry function,diagnostic efficacy,and potential applications of GSN in human cancer.
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