Role of targeting autophagy of hydrogen sulfide in Alzheimer's disease
Alzheimer's disease(AD)is a persistent neurological disorder,its main pathological changes are age spots and neurofibrillary tangles,there is no treatment to prevent its progression currently.Autophagy is an intracellular degradation pathway that maintains cellular homeostasis by removing large insoluble pro-teins.With the deepening of related studies,it is found that the dysfunction of autophagy is related to the pathological process of AD.Hydrogen sulfide(H2S)can regulate autophagy and play a protective role in AD,but the specific mechanism is not fully understood.This paper reviewed the role of H2S in regulating autophagy in the pathological process of AD in recent years,providing new ideas for the prevention and treatment of AD.
万方数据
维普
