Analysis of ADR reports induced by sodium fluorescein injection based on Pareto diagram and evaluation of influencing factors
Objective To analyze the clinical characteristics of adverse drug reactions(ADR)of sodium fluorescein injection in clinical use,and to provide reference for drug safety.Methods A total of 146 cases pa-tients of ADR reports induced by sodium fluorescein injection reported to the national ADR monitoring sys-tem in our hospital from January 2012 to December 2022 were collected.Pareto diagram was used to analyze the ADR involving systems/organs,and the gender,age of patients and manufacturers of sodium fluorescein injection were statistically analyzed.Results There were 194 cases of ADR in 146 patients.The digestive sys-tem was the most common(127 cases,65.46％),followed by respiratory system(40 cases,20.62％)and skin and its accessories(21 cases,10.82％).Age(≥ 60 years old)was a risk factor for ADR of fluorescein sodium injection(P＜0.05).Conclusion Digestive system reaction is the main manifestation of ADR induced by fluorescein sodium injection.The age of patients is the main influencing factor of ADR.It is necessary to provide medication guid-ance for patients with fundus fluorescein angiography to ensure the safety of clinical medication.
Sodium fluorescein injectionAdverse drug reactionsPareto diagramInfluencing factors
万方数据
维普
