Difference and characteristics of serum cytokine expression in patients with chronic hepatitis B with hepatobiliary humid fever and hepatic depression and spleen deficiency syndrome
Difference and characteristics of serum cytokine expression in patients with chronic hepatitis B with hepatobiliary humid fever and hepatic depression and spleen deficiency syndrome
Objective To study serum interleukin(IL)-6,IL-10,IL-17 and transforming growth factor(TGF)-β1 levels in patients with chronic hepatitis B(CHB)with hepatobiliary humid fever and hepatic de-pression and spleen deficiency,to explore the expression differences between different syndromes,and to ex-plore the expression characteristics of cytokines in CHB patients in different liver tissues and pathologies.Methods A total of 138 CHB patients hospitalized in Xiamen Hospital of Traditional Chinese Medicine(TCM)Affiliated to Fujian University of Chinese Medicine from January 2021 to March 2022 were selected,serological indexes and cytokine levels of all the patients were detected,and percutaneous liver biopsy was per-formed simultaneously to obtain histopathological conditions and TCM differentiation classification was per-formed on the patients,and cytokine expression differences in CHB patients with different inflammatory activ-ity and fibrosis stages were compared with those with hepatobiliary humid fever and hepatic depression and spleen deficiency syndrome.Results The expression levels of IL-6 and IL-17 in patients with hepatobiliary humid fever syndrome were higher than those in patients with hepatic depression and spleen deficiency syn-drome(P=0.002,0.025),while the expression levels of IL-10 and TGF-β1 in patients with hepatic depres-sion and spleen deficiency were higher than those in patients with hepatobiliary humid fever syndrome(P=0.001,0.005).According to the results of liver histopathology,there were 31 cases,84 cases,20 cases and three cases of liver inflammatory activity G1-G4 in the 138 CHB patients,and the difference in inflammatory distribution between hepatobiliary humid fever and hepatic depression and spleen deficiency CHB patients was statistically significant(P＜0.05).However,there were 106 cases,26 cases,four cases and two cases of liver fibrosis stage S1-S4 in the 138 CHB patients,and there was no significant difference in the distribution of hepatobiliary humid fever and hepatic depression and spleen deficiency in liver fibrosis stage in the CHB pa-tients(P＞0.05).Conclusion There are differences in cytokine expression level and inflammatory activity between hepatobiliary humid fever and hepatic depression and spleen deficiency syndrome in CHB patients,which is helpful to identify hepatobiliary humid fever and hepatic depression and spleen deficiency syndrome,or can provide a method and treatment strategy for clinical evaluation of the disease and TCM differentiation classification.
维普
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