Study on the value of bone specific alkaline phosphatase and blood calcium in the early diagnosis of rickets
Objective To verify the application value of bone special alkaline phosphatase(BALP)and blood calcium in the early discovery and diagnosis of rickets.Methods A total of 773 children treated in the outpatient department of our hospital from October 2020 to October 2021 were selected,and the symptoms of night terror,hyperhidrosis,irritability,gastrocnemius spasm and pain of both lower limbs were initially screened.BALP was detected by immunofiltration and whole blood dry chemistry.At the same time,the blood calcium levels of the 161 children were randomly detected by polarographic analysis.Results Among the 773 children,139 cases(18.0％)had normal BALP,517 cases(66.9％)had critical BALP,and 117 cases(15.1％)had abnormal BALP.Among all age groups,the highest BALP critical value and outlier detection rates were in the group from one month to less than one year old(62.7％and 22.8％,respectively),and the lowest was in the group greater than or equal to seven years old(63.3％and 6.1％,respectively).The BALP detection val-ues gradually decreased with the increase of age,and the difference between groups was statistically significant(P＜0.05).There was no significant difference in BALP detection values between different genders and dif-ferent seasons(P＞0.05).In 161 children whose BALP and blood calcium levels were measured at the same time,the blood calcium levels were in the normal range.The serum calcium level of the BALP＜250 U/L group was higher than that of the BALP ≥250 U/L group,but the difference was not statistically significant(P＞0.05).Conclusion Compared with blood calcium level,BALP detection in children is more sensitive and simple to operate,which has high application value for early detection and diagnosis of rickets.
Bone special alkaline phosphataseBlood calciumRicketsEarly diagnosis
万方数据
维普
