Objective To investigate the status of disease perception and its related influencing factors in patients with malignant lymphoma(ML),and to provide reference for the formulation and implementation of targeted interventions.Methods A total of 142 ML patients hospitalized in the Department of Hematology of this hospital from February 2021 to March 2022 were investigated by using general information question-naire,simple disease perception questionnaire and fear of disease progression simplified scale.Results The disease perception score of ML patients was(54.81±10.93).The results of multiple linear regression showed that the main influencing factors of disease perception in ML patients were disease stage,family relationship,self-efficacy and fear of disease progression(P<0.05).Conclusion The disease perception of ML patients is at a high level,and there are many factors affecting disease perception.Nursing staff can focus on patients with higher disease stage and poor family relationship,improve their positive cognitive ability and personal self-effi-cacy,so as to promote rehabilitation and improve the quality of life.