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基于组学技术的针灸治疗膝骨关节炎的研究进展

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膝骨关节炎(KOA)是一种好发于中老年人中的膝关节软骨退行性病变。针灸治疗KOA疗效确切,其效应机制较为复杂。组学技术揭示生物体不同组分相互作用和动态变化。组学技术的应用和发展为针灸治疗KOA的效应机制提供新的视野。因此,该文分别综述了基因组学、转录组学、蛋白质组学、代谢组学技术在针灸治疗KOA中的应用,以期从单一组学和多组学层面深入了解针灸治疗KOA的作用机制。
Research progress in the treatment of knee osteoarthritis with acupuncture and moxibustion based on omics technology
Knee osteoarthritis(KOA)is a degenerative disease of the knee joint cartilage that is more common in middle-aged and elderly people.Acupuncture and moxibustion has a definite therapeutic effect on KOA,and its mechanism is complex.Omics techniques reveals the interaction and dynamic changes of differ-ent components in organisms.The application and development of omics technology provide a new perspective for the effect mechanism of acupuncture and moxibustion on KOA.Therefore,this article reviewes the appli-cation of genomics,transcriptomics,proteomics,and metabolomics in the treatment of KOA with acupuncture and moxibustion,in order to deeply understand the mechanism of acupuncture and moxibustion in the treat-ment of KOA from the perspective of monomics and multimics.

Acupuncture and moxibustionKnee osteoarthritisOmics techniquesTraditional Chinese medicine treatmentReview

张峰、周若涵、朱翔宇、王晓彤

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北京中医药大学针灸推拿学院,北京 102401

针灸 膝骨关节炎 组学技术 中药治疗 综述

国家中医药管理局高水平针灸学重点学科项目四川省科技厅苗子工程重点项目北京中医药大学2022年度基本科研业务费揭榜挂帅项目

zyyzdxk-20232542021JDRC01492022-JYB-JYBZ-027

2024

现代医药卫生
重庆市卫生信息中心

现代医药卫生

影响因子:0.758
ISSN:1009-5519
年,卷(期):2024.40(5)
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