Mechanism of Bazhen Decoction in the treatment of breast cancer based on network pharmacology and molecular docking
Objective To investigate the molecular mechanism of Bazhen Decoction against breast canc-er based on network pharmacology and molecular docking.Methods To screen the active ingredients of Ba-zhen Decoction using the data platform,and to screen the targets related to breast cancer using the database.The"drug-compound-target"network was constructed by software,and the affinity between active ingredients and targets was verified by molecular docking.Results A total of 2 336 active ingredients and 211 potential targets were identified in Bazhen Decoction.The molecular docking results showed that the active ingredients quercetin,naringenin and kaempferol had good affinity with the key targets ATK1 and CASP3.Conclusion This study preliminarily clarified the mechanism of action of Bazhen Decoction could be prepared by the active ingredient of kaempferol quercetin,naringenin,etc.acts on key targets such as AKT1 and CASP3.
万方数据
维普
