Clinical study of idiopathic and clonal cytopenia of undetermined significance
Objective To investigate the clinical manifestations and related laboratory diagnosis of pa-tients with idiopathic/clonal cytopenias of undetermined significance(ICUS/CCUS),and to evaluate the prog-nosis.Methods A total of 14 ICUS/CCUS patients diagnosed and treated in the Affiliated Huaian No.1 Peo-ple's Hospital of Nanjing Medical University from January 2019 to February 2021 were selected,including seven ICUS and seven CCUS.The clinical manifestations,bone marrow morphology and pathology,chromo-some and myelodysplastic syndrome fluorescence in situ hybridization(MDS FISH)and gene mutation were analyzed.Results A total of seven ICUS patients were followed up for more than one year and received symp-tomatic supportive treatment,one case progressed to CCUS.Of the seven CCUS patients,two developed MDS with cytoplasmic subtype-1 and one developed acute myeloid leukemia-M5.Conclusion ICUS patients should be followed up regularly,and it is recommended to regularly review the MDS gene mutation detection,which may progress to CCUS.Patients with CCUS with gene mutations that suggest poor prognosis should have reg-ular bone marrow review and early intervention and diagnosis.
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