Diagnostic value of metagenomics next-generation sequencing in pulmonary infection:A meta-analysis of Chinese data
Objective To systematically evaluate the diagnostic value of metagenomic next-generation sequencing(mNGS)for detecting pulmonary infection.Methods PubMed,Embase,Web of Science,the Co-chrane Library,CNKI,WanFang,VIP databases were searched for studies according to the criteria of inclusion and exclusion,enrolling literature recorded from database establishment to May 30,2022.Statistical analysis was performed by Meta-Disc1.4,RevMan5.3 and STATA15.0 software.Results A total of 12 relevant stud-ies were enrolled,including 1 154 patients.The results of meta-analysis showed that the pooled sensitivity was 0.82(95％CI 0.79-0.84,I 2=89.1％),and the pooled specificity was 0.73(95％CI 0.68-0.78,I2=85.4％).The heterogeneity in sensitivity and specificity between studies was significant.The area under the curve(AUC)of the total subject operating characteristic curve(SROC)was 0.850,and the Q index was 0.782.Conclusion The diagnostic performance of mNGS in the clinical application of lung infections is acceptable.
万方数据
维普
